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Published January 2026

Volume 1, Issue 1

4
Articles
1
Volume
2026
Year

Articles in This Issue

Research Article Bioinformatics

Systems-Level Identification Of Metabolic Dysfunction-Associated Steatotic Liver Disease Targets: A Bioinformatics Approach

Authors: Tay Hui Yi*, Sajda Eltaj M. Adam, Wiam Hmidan

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as NAFLD, affects about 30% of adults worldwide and remains without effective pharmacotherapy. Its complex pathogenesis, driven by metabolic dysregulation, oxidative stress, inflammation, and hepatocellular injury, nec…

Keywords: MASLD, NAFLD, Bioinformatics, Pathway Enrichment, Systems Biology, Mitochondrial Dysfunction, Drug Target Identification, Computational Biology
Feb 01, 2026
Pages 29-42
DOI: 10.59324/bmsj.2026.1(1).04
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Review Article Pharmacy

Minireview on CB1 Receptor Allosteric Modulation

Authors: Brenda Chia Ming Yee, Phang Yi Ying, Kong Chek Kouk*

The endocannabinoid system (ECS) constitutes a multifaceted neuromodulatory network orchestrating a spectrum of physiological processes through the interplay of endogenous ligands, metabolic enzymes, and cannabinoid receptors (CB1R and CB2R). Among these, CB1R—an abundantly expressed G protein-coup…

Keywords: CB1 receptor, Allosteric modulation, Endocannabinoid system, Positive allosteric modulators, Negative allosteric modulators, GPCR
Feb 01, 2026
Pages 19-28
DOI: 10.59324/bmsj.2026.1(1).03
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Review Article Research Methods

Protocol for Systematic Review and Meta-Analysis of Pharmacological Interventions in MAFLD: GLP-1 Receptor Agonists as an Exemplar

Authors: Surtika Tamilwanan, Rofaida Alshehade*

Metabolic-associated fatty liver disease (MAFLD) affects approximately 25% of the global population, yet pharmacological treatment options remain limited despite potentially severe complications. Multiple drug classes are under investigation, necessitating standardized evidence-synthesis methodolog…

Keywords: Metabolic-associated fatty liver disease, Systematic review, Meta-analysis, GLP-1 receptor agonists, Pharmacological interventions
Feb 01, 2026
Pages 8-18
DOI: 10.59324/bmsj.2026.1(1).02
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Research Article Pharmacy

Nature's Arsenal Against NAFLD: Computational Analysis of Bioactive Plant Compounds

Authors: Xin Leng Low*, Hui Yi Tay

Non-alcoholic fatty liver disease (NAFLD) presents a significant global health challenge. This study investigates the therapeutic potential of plant-derived compounds in NAFLD treatment using advanced computational techniques. We employed SwissADME, SwissTargetPrediction, SuperPred, and SEA platfor…

Keywords: NAFLD, phytochemicals, computational pharmacology, pathway analysis, drug discovery, metabolic disorders, liver disease, natural compounds
Jan 01, 2026
Pages 1-9
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